The former Puerto Rican lovebirds always seemed destined to be together, but sometimes, love just isn’t enough.
Still, they'll always be one of our favorite former couples! Here's a look back at their romance over the years...
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1998: Love at first sight?
The first time they ever met, Marc says he made a complete fool of himself because for him, it was love at first sight. “I first met Jennifer backstage at The Capeman,” he told the ladies of The Talk. “She walked in and I was just like ‘You are my wife and you don't even know it.’”
1999: Making beautiful music together
Although they weren’t dating at the time, rumors have always run rampant that Marc was making a major push for Lopez when they recorded "No Me Ames", the second single off J.Lo’s debut album, On the 6 (1999).
2004: Ready for some real love
In January 2004, the media frenzy that was Jennifer Lopez’s romance with Benn Affleck came to an abrupt end. Shortly after the Bennifer phase, Lopez quietly began dating her longtime friend Marc.
2004: First comes love, then comes marriage
Jennifer and Marc marry secretly on June 5, 2004 at her home in Beverly Hills, California, just four days after his divorce from Dayanara Torres is final.
2005: Making it official
Jennifer and Marc go public in a big way with a performance at the 47th Annual Grammy Awards at the Staples Center February 13, 2005 in Los Angeles, California.
2007: Working partners
J.Lo & Marc prove that a couple who works together, wins together with the 2007 premiere of El Cantante, which starred both couples in a biopic about legendary performer Hector Lavoe’s life.
Jennifer and Marc announce the birth of their twins, a son Max and a girl, Emme on February 22, 2008 in Long Island, New York.
2009: Political Minded
On January 18, 2009 Marc & Jennifer attend various gala’s in celebration of President Barack Obama’s inauguration. Marc headlines both the Western Gala and the Latino Inaugural Gala.
2009: Happy Valentine’s Day!
Marc & Jennifer show off their babies Max and Emme on stage during Anthony's Valentine's Day show at Madison Square Garden on February 14, 2009 in New York City.
2010: American Idols
J.Lo joins the America Idol cast as a judge and Marc guest stars as a mentor for the contestants. The couple manage to sneak in another joint performance.
2011: Fashionable pair
In May 2011, the couple announce their first joint fashion line together for Kohl’s. Their Fall 2011 line hits stores in September.
2011: Reality Bites
In June 2011, Marc and J.Lo announced their new reality show Q’Viva: The Chosen, which would have the pair traveling all across Latin America to find the best and brightest talent around.
2011: Red Alert?
On June 7, 2011 the couple made their last public appearance together at the Samsung Hope for Children gala at Cipriani Wall Street in New York City.
In a recent interview with People, J.Lo spoke a bit about her highly publicized divorce from Anthony. At the time, she was filming her new crime thriller Parker, and said that she could relate to her character, Leslie. "Leslie had just gone through her own divorce," the superstar said. "It's a bad time in her life."
At the time, Lopez said she felt as though her “world was falling apart.” She and Anthony were married for seven years.